{"product_id":"tesofensine","title":"Tesofensine","description":"\u003cp\u003e\u003cspan class=\"iNqyIf\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\"\u003e\u003cstrong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\"\u003eWhat is Tesofensine?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan class=\"iNqyIf\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\"\u003e\u003cspan class=\"rQesXe MPyX\"\u003eTesofensine is an investigational appetite suppressant medication that was never originally intended to be a diet drug. It was first developed as a treatment for neurodegenerative conditions like Parkinson’s and Alzheimer’s disease. Tesofensine works by altering specific chemical signals in the brain. It belongs to a class of drugs known as triple monoamine reuptake inhibitors, meaning it boosts the levels of three key neurotransmitters, which are dopamine, norepinephrine (noradrenaline), and serotonin. By raising these neurotransmitters, Tesofensine influences the brain circuits that regulate hunger, cravings, and energy expenditure. As a result, it primarily acts as an appetite suppressant and may also modestly increase resting metabolism. Tesofensine helps reduce feelings of hunger while potentially helping the body burn a few more calories at rest. This dual action on appetite and metabolism is what makes Tesofensine a novel candidate in the fight against obesity.\u003c\/span\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cul class=\"XSq4R KI3fJ\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAAgACBoQAQ\" data-complete=\"true\"\u003e\n\u003cli class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAAgACBoQAg\" data-complete=\"true\"\u003e\n\u003cspan class=\"iNqyIf\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\"\u003e\u003cstrong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\"\u003eNeurotransmitter Modulation:\u003c!--TgQPHd|||[]--\u003e\u003c\/strong\u003e It simultaneously inhibits the reuptake transporters for serotonin, norepinephrine, and dopamine, raising their levels in the synaptic cleft.\u003c!--TgQPHd|||[]--\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003c!--TgQPHd|||[]--\u003e\n\u003c\/li\u003e\n\u003cli class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAAgACBoQBw\" data-complete=\"true\"\u003e\n\u003cspan class=\"iNqyIf\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\"\u003e\u003cstrong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\"\u003eAppetite Suppression and Metabolism:\u003c!--TgQPHd|||[]--\u003e\u003c\/strong\u003e By acting centrally in the hypothalamus (including silencing GABAergic neurons and stimulating alpha-1 adrenergic and dopamine D1 pathways), it suppresses appetite, enhances satiety, reduces food cravings, and modestly increases energy expenditure.\u003c!--TgQPHd|||[]--\u003e\u003c\/span\u003e\u003cspan\u003e \u003c\/span\u003e\u003c!--TgQPHd|||[]--\u003e\n\u003c\/li\u003e\n\u003cli class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAAgACBoQDA\" data-complete=\"true\"\u003e\u003cspan class=\"iNqyIf\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\"\u003e\u003cstrong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\"\u003eEfficacy:\u003c!--TgQPHd|||[]--\u003e\u003c\/strong\u003e Phase II clinical trials (such as the TIPO-1 trial) demonstrated significant weight loss—roughly 6.5% to 12% of body weight (or ~10 kg) over 24 weeks depending on the dose (commonly investigated at 0.25 mg to 1.0 mg daily)\u003c\/span\u003e\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"R\u0026R Innovations","offers":[{"title":"Default Title","offer_id":67742223728676,"sku":null,"price":89.99,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0102\/5107\/5620\/files\/tesofensine.jpg?v=1792419085","url":"https:\/\/supplement-addiction.myshopify.com\/products\/tesofensine","provider":"Iron Addiction Supplements","version":"1.0","type":"link"}